Angerer, Erwin von and Egginger, Guenter and Kranzfelder, Gerhard and Bernhauer, Horst and Schönenberger, Helmut (1982) N,N'-Dialkyl-1,2-bis(hydroxyphenyl)ethylenediamines and N,N'-dialkyl-4,5-bis(4-hydroxyphenyl)imidazolidines. Syntheses and evaluation of their mammary tumor inhibiting activity. Journal of Medicinal Chemistry 25 (7), pp. 832-837.
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Diastereomeric N,”-dialkyl- 1,2-bis(hydroxyphenyl)ethylenediamines (5) were synthesized and tested for their affinity for the estradiol receptor. Only the (&)-1,2-bis(4-hydroxyphenyl)ethylenediamines with the alkyl groups C3H7 [ (&)-5c, K, = 1.1 X lo6)],C ,H9 [(&)-5e,K=, 3.6 X lo6], and CSHll [(*)-5h, K, = 2.2 X lo6] showed a marked affinity, which is mainly due to the (+) enantiomers [e.g., ...
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|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger|
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||17 May 2010 12:12|
|Last Modified:||13 Mar 2014 13:28|