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Computational and Experimental Evidence for the Evolution of a (betaalpha)(8)-Barrel Protein from an Ancestral Quarter-Barrel Stabilised by Disulfide Bonds

Richter, Markus and Bosnali, Manal and Carstensen, Linn and Seitz, Tobias and Durchschlag, Helmut and Blanquart, Samuel and Merkl, Rainer and Sterner, Reinhard (2010) Computational and Experimental Evidence for the Evolution of a (betaalpha)(8)-Barrel Protein from an Ancestral Quarter-Barrel Stabilised by Disulfide Bonds. J Mol Biol 398, pp. 763-773.

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Other URL: http://dx.doi.org/10.1016/j.jmb.2010.03.057


Abstract

The evolution of the prototypical (beta alpha)(8)-barrel protein imidazole glycerol phosphate synthase (HisF) was studied by complementary computational and experimental approaches. The 4-fold symmetry of HisF suggested that its constituting (beta alpha)(2) quarter-barrels have a common evolutionary origin. This conclusion was supported by the computational reconstruction of the HisF sequence of ...

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Item Type:Article
Date:7 April 2010
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner > Arbeitsgruppe PD Dr. Rainer Merkl
Keywords:protein evolution; (βα)8-barrel; sequence reconstruction; disulfide bond
Subjects:500 Science > 570 Life sciences
000 Computer science, information & general works > 004 Computer science
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Rainer Merkl
Deposited On:19 May 2010 06:41
Last Modified:02 Jul 2010 07:22
Item ID:14996
Owner Only: item control page
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