Jakse, G. and Hofstädter, Ferdinand and Engelmann, U. and Jacobi, G. H. (1983) ABH-antigenicity of transitional cell carcinoma of the urinary bladder in patients subjected to topical chemoprophylaxis. World Journal of Urology = World J Urol 1, pp. 82-85.
Full text not available from this repository.
Topical chemoprophylaxis with adriamycin
was administered to 49 patients with UICC-stages pTA
and PT1 (pathological stage 0 and A) of transitional cell
carcinoma of the urinary bladder. Tumor specimens obtained
prior to initiation of the instillation protocol were
evaluated with regard to ABH-antigenicity. ABH-antigens
were present in tumors of 19 patients and none of
these developed muscle-infiltrating recurrences during
or after intravesical chemoprophylaxis. The primary
lesions of 30 patients were deleted of antigens; only 5
(16%) developed a progressive recurrence. Compared to
a historical control group this is thought to be a true reduction
of invasive tumor recurrences in ABH-negative
tumors by adriamycin. We herein propose that ABHantigenicity
may serve as a valuable prescreening indicator
for or against topical chemoprophylaxis.
|Institutions:||Medicine > Lehrstuhl für Pathologie|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||26 May 2010 07:20|
|Last Modified:||26 May 2010 07:20|