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Inhibition of the estradiol-induced growth of cultured human breast cancer cells by the anti-estrogens tamoxifen, desmethyl-tamoxifen, 4-hydroxy-tamoxifen and enclomiphene

Marth, C. and Daxenbichler, G. and Buehring, G. C. and Hofstädter, Ferdinand and Dapunt, O. (1984) Inhibition of the estradiol-induced growth of cultured human breast cancer cells by the anti-estrogens tamoxifen, desmethyl-tamoxifen, 4-hydroxy-tamoxifen and enclomiphene. Biochemical pharmacology 33 (24), pp. 3951-5956.

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Abstract

The growth effects of tamoxifen (T), desmethyl-tamoxifen (dMeT), 4-hydroxy-tamoxifen (OHT) and enclomiphene (Clo) on cultured human breast cancer cell lines have been related to published binding affinities for the estrogen receptor. Only in cells which were stimulated by estrogens did these anti-estrogens markedly inhibit growth. In both estrogen sensitive cell lines tested, 734 B and ZR 75.1, ...

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Item Type:Article
Date:1984
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
6439216PubMed ID
Classification:
NotationType
Breast Neoplasms/pathologyMESH
Cell Division/drug effectsMESH
Cells, CulturedMESH
Clomiphene/pharmacologyMESH
Estradiol Antagonists/pharmacologyMESH
FemaleMESH
HumansMESH
Receptors, Estrogen/drug effectsMESH
Tamoxifen/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:31 May 2010 13:44
Last Modified:31 May 2010 13:44
Item ID:15079
Owner Only: item control page
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