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Sensitivities of monolayers and spheroids of the human bladder cancer cell line MGH-U1 to the drugs used for intravesical chemotherapy

Knüchel, R. and Hofstädter, Ferdinand and Jenkins, W. E. and Masters, J. R. (1989) Sensitivities of monolayers and spheroids of the human bladder cancer cell line MGH-U1 to the drugs used for intravesical chemotherapy. Cancer research 49 (6), pp. 1397-1401.

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Abstract

The in vitro cytotoxicities of the four drugs most frequently used for intravesical chemotherapy (Adriamycin, epodyl, mitomycin C, Thiotepa) and epirubicin were compared using monolayers and multicellular tumor spheroids of the human bladder cancer cell line, MGH-U1. Adriamycin and epirubicin were most cytotoxic against monolayer cultures, whereas mitomycin C killed more cells in spheroids. ...

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Item Type:Article
Date:1989
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
2493980PubMed ID
Classification:
NotationType
Administration, TopicalMESH
Bromodeoxyuridine/metabolismMESH
Carcinoma, Transitional Cell/pathologyMESH
Cell Survival/drug effectsMESH
DNA, Neoplasm/biosynthesisMESH
Doxorubicin/pharmacologyMESH
Drug Screening Assays, AntitumorMESH
HumansMESH
Thiotepa/pharmacologyMESH
Tumor Cells, Cultured/drug effectsMESH
Urinary Bladder Neoplasms/pathologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:09 Jun 2010 14:33
Last Modified:09 Jun 2010 14:33
Item ID:15222
Owner Only: item control page
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