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Effect of fluoride on aluminum-induced bone disease in rats with renal failure

Ittel, T. H. and Gruber, E. and Heinrichs, A. and Handt, S. and Hofstädter, Ferdinand and Sieberth, H.G. (1992) Effect of fluoride on aluminum-induced bone disease in rats with renal failure. Kidney international 41 (5), pp. 1340-1348.

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Abstract

Aluminum (Al) accumulation in renal failure is an etiological factor in the pathogenesis of low turnover bone disease. Aluminum-induced impairment of mineralization has been related to a reduced extent of active bone-forming surface. The present study investigated the effect of fluoride, a potent stimulator of osteoblast number, on the toxicity of aluminum in rats with renal failure (Nx). ...

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Item Type:Article
Date:1992
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
1614048PubMed ID
Classification:
NotationType
Aluminum/toxicityMESH
AnimalsMESH
Bone Diseases/pathologyMESH
Fluorides/pharmacologyMESH
Kidney Failure, Chronic/complicationsMESH
MaleMESH
Minerals/metabolismMESH
Osteoblasts/pathologyMESH
Osteomalacia/pathologyMESH
RatsMESH
Rats, Inbred StrainsMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:09 Jun 2010 14:50
Last Modified:09 Jun 2010 14:50
Item ID:15257
Owner Only: item control page
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