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Cellular nanoparticle delivery by G-protein coupled receptors

URN to cite this document: urn:nbn:de:bvb:355-epub-153147

Hild, Wolfgang (2012) Cellular nanoparticle delivery by G-protein coupled receptors. PhD, Universität Regensburg

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Abstract (English)

Considering the significant benefits that site-specific drug therapy offers, in this work, the potential of G-protein-coupled receptors (GPCRs) as candidates for a new class of targets in the field of drug targeting was investigated. In order to evaluate this potential at the cellular level, nanoparticles were conjugated with specific ligands for the human neuropeptide Y (hNPY) Y1 receptor and ...

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Translation of the abstract (German)

In Anbetracht der signifikanten Vorteile, die eine zielgerichtete Pharmakotherapie bietet, wurde in dieser Arbeit untersucht, welches Potential G-Protein gekoppelte Rezeptoren (GPCRs) als neue Klasse von Zielstrukturen im Bereich des Nanopartikel-Targeting aufweisen. Um dies auf zellulärer Ebene zu bestimmen, wurden Nanopartikel mit Liganden spezifisch für den menschlichen Neuropeptid Y (hNPY) ...

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Item Type:Thesis of the University of Regensburg (PhD)
Date:14 June 2012
Referee:Prof. Dr. Achim Göpferich and Prof. Dr. Jörg Heilmann and Prof. Dr. Frank-Michael Matysik
Date of exam:7 May 2010
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Keywords:GPCR, neuropeptide Y, NPY, quantum dot, nanoparticle, drug targeting, uptake
Subjects:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:14 Jun 2012 08:28
Last Modified:13 Mar 2014 18:54
Item ID:15314
Owner Only: item control page

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