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A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis

Michel, J. and Langstein, J. and Hofstädter, Ferdinand and Schwarz, H. (1998) A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis. European journal of immunology 28 (1), pp. 290-295.

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Abstract

CD137 (ILA/4-1BB) is a member of the tumor necrosis factor receptor family and regulates activation, proliferation and programmed cell death in T lymphocytes. Here we show the existence of a soluble form of CD137 (sCD137) of 16 kDa. sCD137 is released by activated lymphocytes, and in contrast to membrane-bound CD137, expression of sCD137 seems to be restricted to lymphocytes. sCD137 is generated ...

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Item Type:Article
Date:1998
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
9485208PubMed ID
10.1002/(SICI)1521-4141(199801)28:01<290::AID-IMMU290>3.0.CO;2-SDOI
Classification:
NotationType
Antigens, CDMESH
Antigens, CD137MESH
Arthritis, Rheumatoid/bloodMESH
Enzyme-Linked Immunosorbent AssayMESH
HumansMESH
Lymphocyte ActivationMESH
Lymphocytes/secretionMESH
Polymerase Chain ReactionMESH
RNA SplicingMESH
Receptors, Nerve Growth Factor/geneticsMESH
Receptors, Tumor Necrosis Factor/geneticsMESH
SolubilityMESH
Tumor Cells, CulturedMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:17 Jun 2010 08:20
Last Modified:17 Jun 2010 08:20
Item ID:15346
Owner Only: item control page
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