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Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection

Rüschoff, J. and Wallinger, S. and Dietmaier, W. and Bocker, T. and Brockhoff, G. and Hofstädter, Ferdinand and Fishel, R. (1998) Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection. Proceedings of the National Academy of Sciences of the United States of America: PNAS 95 (19), pp. 11301-11306.

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Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are well-known cancer preventives, which have been largely attributed to their antiproliferative and apoptosis-inducing activities. In this study, we show that microsatellite instability (MSI) in colorectal cancer cells deficient for a subset of the human mismatch repair (MMR) genes (hMLH1, hMSH2, and hMSH6), is markedly reduced during exposure to ...

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Item Type:Article
Date:1998
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
7497146PubMed ID
Classification:
NotationType
Adaptor Proteins, Signal TransducingMESH
Anti-Inflammatory Agents, Non-Steroidal/pharmacologyMESH
Apoptosis/geneticsMESH
Aspirin/pharmacologyMESH
Carrier ProteinsMESH
ChemopreventionMESH
Clone Cells/metabolismMESH
Cloning, MolecularMESH
Colorectal Neoplasms, Hereditary Nonpolyposis/therapyMESH
DNA Repair/geneticsMESH
DNA-Binding ProteinsMESH
Fungal Proteins/geneticsMESH
HumansMESH
Microsatellite Repeats/geneticsMESH
MutS Homolog 2 ProteinMESH
Mutation/geneticsMESH
Neoplasm Proteins/geneticsMESH
Nuclear ProteinsMESH
PhenotypeMESH
Proto-Oncogene Proteins/geneticsMESH
Saccharomyces cerevisiae ProteinsMESH
SulindacMESH
Time FactorsMESH
Tumor Cells, CulturedMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:17 Jun 2010 08:19
Last Modified:17 Jun 2010 08:19
Item ID:15349
Owner Only: item control page
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