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Clonality and genetic divergence in multifocal low-grade superficial urothelial carcinoma as determined by chromosome 9 and p53 deletion analysis

Hartmann, A. and Rösner, U. and Schlake, G. and Dietmaier, W. and Zaak, D. and Hofstaedter, Ferdinand and Knuechel, R. (2000) Clonality and genetic divergence in multifocal low-grade superficial urothelial carcinoma as determined by chromosome 9 and p53 deletion analysis. Laboratory investigation: Lab Inv 80 (5), pp. 709-718.

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Abstract

Multifocality and recurrence are clinically important features of urothelial carcinomas of the urinary bladder. Recent molecular genetic studies have suggested that multifocal urothelial carcinomas are monoclonally derived from an identical transformed progenitor cell. However, most of these studies investigated advanced and poorly differentiated tumors. The study presented focuses on early ...

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Item Type:Article
Date:2000
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
10830781PubMed ID
Classification:
NotationType
AgedMESH
Chromosomes, Human, Pair 9MESH
Genes, p53MESH
HumansMESH
In Situ Hybridization, FluorescenceMESH
Loss of HeterozygosityMESH
MaleMESH
Microsatellite RepeatsMESH
Middle AgedMESH
Urinary Bladder Neoplasms/pathologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:17 Jun 2010 08:52
Last Modified:17 Jun 2010 08:52
Item ID:15365
Owner Only: item control page
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