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Microsatellite instability in tumor and nonneoplastic colorectal cells from hereditary non-polyposis colorectal cancer and sporadic high microsatellite-instable tumor patients

Dietmaier, W. and Gänsbauer, S. and Beyser, K. and Renke, B. and Hartmann, A. and Rümmele, P. and Jauch, K.W. and Hofstädter, Ferdinand and Rüschoff, J. (2000) Microsatellite instability in tumor and nonneoplastic colorectal cells from hereditary non-polyposis colorectal cancer and sporadic high microsatellite-instable tumor patients. Pathobiology 68 (4-5), pp. 227-231.

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Abstract

Genetic alterations such as loss of heterozygosity (LOH) and microsatellite instability (MSI) have been frequently studied in various tumor types. Genetic heterogeneity of nonneoplastic cells has not yet been sufficiently investigated. However, genomic instability in normal cells could be a potentially important issue, in particular when these cells are used as reference in LOH and MSI analyses ...

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Item Type:Article
Date:2000
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
11279351PubMed ID
Classification:
NotationType
Cell Separation/methodsMESH
Colon/pathologyMESH
Colorectal Neoplasms, Hereditary Nonpolyposis/pathologyMESH
Dissection/methodsMESH
HumansMESH
Intestinal Mucosa/pathologyMESH
LasersMESH
Microsatellite Repeats/geneticsMESH
Rectum/pathologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:17 Jun 2010 08:07
Last Modified:17 Jun 2010 08:07
Item ID:15368
Owner Only: item control page
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