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Occurrence of chromosome 9 and p53 alterations in multifocal dysplasia and carcinoma in situ of human urinary bladder

Hartmann, Arndt and Schlake, Gudrun and Zaak, Dirk and Hungerhuber, Edwin and Hofstetter, Alfons and Hofstaedter, Ferdinand and Knuechel, Ruth (2002) Occurrence of chromosome 9 and p53 alterations in multifocal dysplasia and carcinoma in situ of human urinary bladder. Cancer Research 62 (3), pp. 809-818.

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Abstract

To define the genetic changes of flat urothelial lesions, carcinoma in situ (CIS) and moderate dysplasias (DII) were investigated for alterations in the two chromosomal regions most frequently involved in bladder cancer. Overall, 33 CIS and 16 DII from 21 patients were used to microdissect urothelium. Dual color fluorescence in situ hybridization (FISH) using gene locus probes of 9q22 (FACC), ...

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Item Type:Article
Date:2002
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
11830537PubMed ID
Classification:
NotationType
AgedMESH
Aged, 80 and overMESH
Aminolevulinic Acid/diagnostic useMESH
Carcinoma in Situ/geneticsMESH
Chromosome AberrationsMESH
Chromosomes, Human, Pair 17/geneticsMESH
Chromosomes, Human, Pair 9MESH
ExonsMESH
FemaleMESH
Gene DeletionMESH
Genes, p53/geneticsMESH
HumansMESH
In Situ Hybridization, FluorescenceMESH
Loss of HeterozygosityMESH
MaleMESH
Middle AgedMESH
Photosensitizing Agents/diagnostic useMESH
Precancerous Conditions/geneticsMESH
Urinary Bladder/pathologyMESH
Urinary Bladder Neoplasms/geneticsMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:18 Jun 2010 08:59
Last Modified:18 Jun 2010 08:59
Item ID:15401
Owner Only: item control page
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