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Non-viral liposomal keratinocyte growth factor (KGF) cDNA gene transfer improves dermal and epidermal regeneration through stimulation of epithelial and mesenchymal factors

Jeschke, M. G. and Richter, G. and Hofstädter, Ferdinand and Herndon, D. N. and Perez-Polo, J.-R. and Jauch, K.-W. (2002) Non-viral liposomal keratinocyte growth factor (KGF) cDNA gene transfer improves dermal and epidermal regeneration through stimulation of epithelial and mesenchymal factors. Gene therapy 9 (16), pp. 1065-1074.

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Abstract

Keratinocyte growth factor (KGF) stimulates epithelial cell differentiation and proliferation, which are of major importance for wound healing. Local protein administration, however, has been shown to be ineffective due to enzymes and proteases in the wound fluid. We hypothesized that delivering KGF as a non-viral liposomal cDNA gene complex is a new approach that would effectively enhance dermal ...

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Item Type:Article
Date:2002
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
12140734PubMed ID
10.1038/sj.gt.3301732DOI
Classification:
NotationType
AnimalsMESH
ApoptosisMESH
Burns/therapyMESH
Cell DivisionMESH
Collagen/metabolismMESH
DNA, Complementary/administration & dosageMESH
Epidermis/physiologyMESH
Fibroblast Growth Factor 7MESH
Fibroblast Growth Factors/metabolismMESH
Gene Therapy/methodsMESH
Gene Transfer TechniquesMESH
Insulin-Like Growth Factor I/metabolismMESH
LiposomesMESH
MaleMESH
RatsMESH
Rats, Sprague-DawleyMESH
RegenerationMESH
Skin/pathologyMESH
Skin Physiological PhenomenaMESH
TransfectionMESH
Wound HealingMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Yes
Owner: Gertraud Kellers
Deposited On:18 Jun 2010 08:53
Last Modified:18 Jun 2010 08:53
Item ID:15402
Owner Only: item control page
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