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WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer

Wissmann, Christoph and Wild, Peter Johannes and Kaiser, Simone and Roepcke, Stefan and Stoehr, Robert and Woenckhaus, Matthias and Kristiansen, Glen and Hsieh, Jen-Chih and Hofstaedter, Ferdinand and Hartmann, Arndt and Knuechel, Ruth and Rosenthal, André and Pilarsky, Christian (2003) WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer. The Journal of pathology 201 (2), pp. 204-212.

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Abstract

To detect novel Wnt-pathway genes involved in tumourigenesis, this study analysed the RNA expression levels of 40 genes of the Wnt pathway by chip hybridization of microdissected matched pairs of 54 primary prostate carcinomas. Eleven genes showed greater than two-fold differential expression in at least 10% of prostate cancers. Three of these genes encode extracellular components of the Wnt ...

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Item Type:Article
Date:2003
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
14517837PubMed ID
10.1002/path.1449DOI
Classification:
NotationType
Adaptor Proteins, Signal TransducingMESH
AgedMESH
Blotting, Northern/methodsMESH
Breast Neoplasms/chemistryMESH
Gene Expression RegulationMESH
Genes, Tumor SuppressorMESH
HumansMESH
Immunohistochemistry/methodsMESH
Lung Neoplasms/chemistryMESH
MaleMESH
Middle AgedMESH
Neoplasms/chemistryMESH
Oligonucleotide Array Sequence AnalysisMESH
Prostatic Neoplasms/chemistryMESH
Repressor ProteinsMESH
Reverse Transcriptase Polymerase Chain ReactionMESH
Statistics, NonparametricMESH
Transcription Factors/geneticsMESH
Tumor Markers, Biological/analysisMESH
Urinary Bladder Neoplasms/chemistryMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:18 Jun 2010 08:38
Last Modified:18 Jun 2010 08:38
Item ID:15409
Owner Only: item control page
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