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Histologic-genetic mapping by allele-specific PCR reveals intraurothelial spread of p53 mutant tumor clones

Stoehr, Robert and Knuechel, Ruth and Boecker, Joerg and Blaszyk, Hagen and Schmitt, Ruediger and Filbeck, Thomas and Hofstaedter, Ferdinand and Hartmann, Arndt (2002) Histologic-genetic mapping by allele-specific PCR reveals intraurothelial spread of p53 mutant tumor clones. Laboratory investigation 82 (11), pp. 1553-1561.

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Abstract

Common and clinically important features of urothelial carcinomas are multifocality and a high rate of recurrence. Molecular studies demonstrated that multifocal tumors are frequently composed of one tumor clone spreading throughout the urothelial tract. A combination of histologic and genetic mapping of cystectomy specimens from bladder cancer patients is a valuable tool to study bladder ...

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Item Type:Article
Date:2002
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
12429815PubMed ID
Classification:
NotationType
AgedMESH
AllelesMESH
FemaleMESH
Genes, p53MESH
HumansMESH
ImmunohistochemistryMESH
Loss of HeterozygosityMESH
MaleMESH
Middle AgedMESH
MutationMESH
Polymerase Chain Reaction/methodsMESH
Tumor Suppressor Protein p53/analysisMESH
Urinary Bladder Neoplasms/pathologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:18 Jun 2010 08:34
Last Modified:18 Jun 2010 08:34
Item ID:15417
Owner Only: item control page
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