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MethyQESD, a robust and fast method for quantitative methylation analyses in HNPCC diagnostics using formalin-fixed and paraffin-embedded tissue samples

Bettstetter, Marcus and Dechant, Stefan and Ruemmele, Petra and Vogel, Corinna and Kurz, Katrin and Morak, Monika and Keller, Gisela and Holinski-Feder, Elke and Hofstaedter, Ferdinand and Dietmaier, Wolfgang (2008) MethyQESD, a robust and fast method for quantitative methylation analyses in HNPCC diagnostics using formalin-fixed and paraffin-embedded tissue samples. Laboratory investigation 88 (12), pp. 1367-1375.

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Abstract

Promoter hypermethylation occurs in various tumors and leads to silencing of tumor-relevant genes. Thus, promoter methylation analysis (MA) has been established as an important tool in cancer research and diagnostics. Here we present MethyQESD (methylation-quantification of endonuclease-resistant DNA) as a fast, easy, precise and reliable method for quantitative MA without the need of ...

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Item Type:Article
Date:2008
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
18936738PubMed ID
10.1038/labinvest.2008.100DOI
Classification:
NotationType
Adaptor Proteins, Signal Transducing/geneticsMESH
Base SequenceMESH
Colorectal Neoplasms, Hereditary Nonpolyposis/diagnosisMESH
DNA MethylationMESH
DNA PrimersMESH
FormaldehydeMESH
HumansMESH
Nuclear Proteins/geneticsMESH
Paraffin EmbeddingMESH
Promoter Regions, GeneticMESH
ROC CurveMESH
Reproducibility of ResultsMESH
Tissue FixationMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:18 Jun 2010 08:31
Last Modified:18 Jun 2010 08:31
Item ID:15419
Owner Only: item control page
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