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No evidence for involvement of beta-catenin and APC in urothelial carcinomas

Stoehr, Robert and Krieg, Rene C. and Knuechel, Ruth and Hofstaedter, Ferdinand and Pilarsky, Christian and Zaak, Dirk and Schmitt, Ruediger and Hartmann, Arndt (2002) No evidence for involvement of beta-catenin and APC in urothelial carcinomas. International journal of oncology 20 (5), pp. 905-911.

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Abstract

The wnt pathway plays an important role in embryonal patterning and cell fate determination, involving stabilization of nuclear and cytoplasmic beta-catenin (CTNNB1) mediated by APC, axin, and other proteins. Uncomplexed beta-catenin binds to TCF/LEF transcription factors and activates the expression of growth regulatory target genes such as c-myc or cyclin D1. In colorectal and other cancers, ...

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Item Type:Article
Date:2002
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
11956582PubMed ID
Classification:
NotationType
Adenomatous Polyposis Coli Protein/geneticsMESH
AllelesMESH
Base SequenceMESH
Carcinoma/metabolismMESH
Chromosomes, Human, Pair 5MESH
CodonMESH
Cytoskeletal Proteins/geneticsMESH
ExonsMESH
HeterozygoteMESH
HomozygoteMESH
HumansMESH
Loss of HeterozygosityMESH
Microsatellite Repeats/geneticsMESH
Microscopy, FluorescenceMESH
Molecular Sequence DataMESH
MutationMESH
Polymorphism, GeneticMESH
Trans-Activators/geneticsMESH
Tumor Cells, CulturedMESH
Urinary Bladder Neoplasms/metabolismMESH
Urothelium/metabolismMESH
beta CateninMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:18 Jun 2010 08:26
Last Modified:18 Jun 2010 08:26
Item ID:15422
Owner Only: item control page
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