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Microsatellite instability at chromosome 8p in non-small cell lung cancer is associated with lymph node metastasis and squamous differentiation

Woenckhaus, Matthias and Stoehr, Robert and Dietmaier, Wolfgang and Wild, Peter J. and Zieglmeier, Ulrike and Foerster, Julia and Merk, Johannes and Blaszyk, Hagen and Pfeifer, Michael and Hofstaedter, Ferdinand and Hartmann, Arndt (2003) Microsatellite instability at chromosome 8p in non-small cell lung cancer is associated with lymph node metastasis and squamous differentiation. International journal of oncology 23 (5), pp. 1357-1363.

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Abstract

Genetic alterations at chromosome arm 8p are associated with advanced disease and poor patient outcome in several types of malignant tumors. We studied the frequency of microsatellite instability (MSI) and loss of heterozygosity (LOH) at chromosome 8p in early stage non-small cell lung cancer (NSCLC) of 47 patients with stage I or II disease (25 squamous cell carcinomas and 22 adenocarcinomas). ...

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Item Type:Article
Date:2003
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
14532977PubMed ID
Classification:
NotationType
Adaptor Proteins, Signal TransducingMESH
Carcinoma, Non-Small-Cell Lung/geneticsMESH
Carcinoma, Squamous Cell/geneticsMESH
Carrier ProteinsMESH
Cell Cycle ProteinsMESH
Cell DifferentiationMESH
Chromosomes, Human, Pair 8MESH
DNA/chemistryMESH
DNA RepairMESH
DNA Sequence, UnstableMESH
DNA-Binding Proteins/biosynthesisMESH
HumansMESH
ImmunohistochemistryMESH
Loss of HeterozygosityMESH
Lung Neoplasms/geneticsMESH
Lymphatic MetastasisMESH
Microsatellite RepeatsMESH
MutS Homolog 2 ProteinMESH
Neoplasm MetastasisMESH
Neoplasm Proteins/biosynthesisMESH
Nuclear ProteinsMESH
Polymerase Chain ReactionMESH
Polymorphism, GeneticMESH
Protein BiosynthesisMESH
ProteinsMESH
Proto-Oncogene Proteins/biosynthesisMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:18 Jun 2010 08:23
Last Modified:18 Jun 2010 08:23
Item ID:15427
Owner Only: item control page
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