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No evidence for mutation of B-RAF in urothelial carcinomas of the bladder and upper urinary tract

Stoehr, Robert and Brinkmann, Anke and Filbeck, Thomas and Gamper, Christoph and Wild, Peter and Blaszyk, Hagen and Hofstaedter, Ferdinand and Knuechel, Ruth and Hartmann, Arndt (2004) No evidence for mutation of B-RAF in urothelial carcinomas of the bladder and upper urinary tract. Oncology reports 11 (1), pp. 137-141.

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Abstract

Mutational activation of the MAP kinase pathway is frequently found in various cancers. Recently, activating mutations in the B-RAF gene, an important activator of this pathway, have been described in several tumor types including melanoma, colorectal and papillary thyroid cancer. The most frequent mutation in exon 15 (V599E), as well as several other mutations within exons 11 and 15 result in ...

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Item Type:Article
Date:2004
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
14654916PubMed ID
Classification:
NotationType
AgedMESH
Aged, 80 and overMESH
AllelesMESH
Base SequenceMESH
Carcinoma, Transitional Cell/pathologyMESH
DNA Mutational AnalysisMESH
DNA, Neoplasm/geneticsMESH
Exons/geneticsMESH
FemaleMESH
HT29 CellsMESH
HumansMESH
MaleMESH
Middle AgedMESH
MutationMESH
Polymerase Chain Reaction/methodsMESH
Protein-Serine-Threonine Kinases/geneticsMESH
Proto-Oncogene Proteins B-rafMESH
Proto-Oncogene Proteins c-raf/geneticsMESH
Ureteral Neoplasms/pathologyMESH
Urinary Bladder Neoplasms/pathologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:22 Jun 2010 09:54
Last Modified:22 Jun 2010 09:54
Item ID:15430
Owner Only: item control page
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