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FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization

Hafner, Christian and Hartmann, Arndt and van Oers, Johanna M. M. and Stoehr, Robert and Zwarthoff, Ellen C. and Hofstaedter, Ferdinand and Landthaler, Michael and Vogt, Thomas (2007) FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20 (8), pp. 895-903.

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Abstract

Somatic activating fibroblast growth factor 3 (FGFR3) mutations in human skin can cause seborrheic keratoses, one of the most frequent skin tumors in man. However, details of the involved mechanisms remain elusive. We analyzed 65 acanthotic seborrheic keratoses with varying vertical diameters for FGFR3 mutations using a SNaPshot multiplex assay. Immunohistochemistry was performed for Ki-67, bcl-2 ...

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Item Type:Article
Date:2007
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
17585316PubMed ID
10.1038/modpathol.3800837DOI
Classification:
NotationType
AdultMESH
Age FactorsMESH
AgedMESH
Aged, 80 and overMESH
ApoptosisMESH
Cell ProliferationMESH
DNA Mutational AnalysisMESH
FemaleMESH
Gene Expression Regulation, NeoplasticMESH
Genetic Predisposition to DiseaseMESH
Head and Neck Neoplasms/pathologyMESH
HumansMESH
ImmunohistochemistryMESH
Keratosis, Seborrheic/pathologyMESH
Ki-67 Antigen/analysisMESH
MaleMESH
Middle AgedMESH
MutationMESH
Proto-Oncogene Proteins c-bcl-2/analysisMESH
Receptor, Fibroblast Growth Factor, Type 3/geneticsMESH
Risk FactorsMESH
Skin Neoplasms/pathologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:22 Jun 2010 14:05
Last Modified:22 Jun 2010 14:05
Item ID:15530
Owner Only: item control page
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