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Cardiovascular effects of modulators of soluble guanylyl cyclase activity.

Hoenicka, Markus and Schmid, Christof (2008) Cardiovascular effects of modulators of soluble guanylyl cyclase activity. Cardiovascular & hematological agents in medicinal chemistry 6 (4), pp. 287-301.

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Abstract

Soluble guanylyl cyclase (sGC) is one of the key enzymes of the nitric-oxide (NO)/cyclic 3',5'-guanosine monophosphate (cGMP) pathway. Located in virtually all mammalian cells, it controls the vessel tone, smooth muscle cell growth, platelet aggregation, and leukocyte adhesion. In vivo sGC activity is mainly regulated by NO which in turn is released from L-arginine by nitric oxide synthases. One ...

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Item Type:Article
Date:2008
Institutions:Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie
Identification Number:
ValueType
18855642PubMed ID
Classification:
NotationType
AnimalsMESH
Atherosclerosis/etiologyMESH
Carbon Monoxide/physiologyMESH
Cardiovascular Agents/pharmacologyMESH
Cyclic GMP/physiologyMESH
Guanylate Cyclase/physiologyMESH
HumansMESH
Hypertension/etiologyMESH
Hypertension, Pulmonary/etiologyMESH
Nitric Oxide/physiologyMESH
Nitric Oxide Donors/pharmacologyMESH
Signal TransductionMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Markus Hoenicka
Deposited On:05 Jul 2010 15:31
Last Modified:13 Mar 2014 13:45
Item ID:15657
Owner Only: item control page

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