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Degradation of 1-Benzyl-1,2,3,4-tetrahydroisoquinolines (Laudanosine) with Ethyl chloroformate: Gedamer's Intermediate

Angerer, S. von and Eibler, E. and Lee, D.-U. and Wiegrebe, Wolfgang (1989) Degradation of 1-Benzyl-1,2,3,4-tetrahydroisoquinolines (Laudanosine) with Ethyl chloroformate: Gedamer's Intermediate. Scientia Pharmaceutica (Sci. Pharm.) 57, pp. 1-6.

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Abstract

Gadamer has postulated the α-chlorobisbenzyl derivate 2a as an intermediate of the degradation of laudanosine [(-)-1] to the stilbene 3 by ethyl chloroformate. Optically active 2a is easily hydrolyzed to the corresponding carbinol 2b. The optical purity of 2b is determined via diastereomeric esters. Als Zwischenprodukt des Chlorameisensäureethylester-Abbaus von Laudanosin [(-)-)1] ...

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Item Type:Article
Date:1989
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Wiegrebe
Keywords:1-Benzyl-1,2,3,4-tetrahydroisoquinolines, Ethyl chloroformate, Mosher-Esters
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:08 Jul 2010 04:45
Last Modified:13 Mar 2014 13:47
Item ID:15694
Owner Only: item control page
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