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Synthesis and Antitumor Activity of Methoxy-indolo[2,1-a]isoquinolines

Ambros, R. and Angerer, S. von and Wiegrebe, Wolfgang (1988) Synthesis and Antitumor Activity of Methoxy-indolo[2,1-a]isoquinolines. Archiv der Pharmazie 321, pp. 481-486.

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Methoxy-indolo[2,1-a]isoquinolines 8a-f and their dihydroderivatives 7a-f were synthesized by Bischler-Napieralski reaction of the (bromomethoxyphenyl)-[ 2-(methoxyphenyl)-ethyl]acetamides 4a-f, reduction, subsequent cyclization and dehydrogenation. They were tested for cytostatic activity in vitro using P388 D1 leukemia and MDA MB 231 mammary tumor cells. The ...


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Item Type:Article
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Wiegrebe
Subjects:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:07 Jul 2010 05:15
Last Modified:13 Mar 2014 13:47
Item ID:15695
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