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Methoxy- and Acetoxy-8-oxoberbines-Synthesis, Antitumor-Activity, and Interaction with DNA

Weimar, C. and Angerer, S. von and Wiegrebe, Wolfgang (1991) Methoxy- and Acetoxy-8-oxoberbines-Synthesis, Antitumor-Activity, and Interaction with DNA. Archiv der Pharmazie 324, pp. 509-518.

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Abstract

Most of the memoxy-8H-dibenzo[a,g]isoquinolin-8-ones 3a-h and their acetoxy derivatives 6a-e were synthesized by condensation of 1-oxo-1,2,3,4-tetrahydroisoquinolines 4a-c and homophthalic acid anhydrides 5a and b, ether cleavage and acetylation. These protoberberinones were tested for cytostatic activity in vitro using MDA-MB-231 mammary tumor cells and for interaction with native calf ...

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Item Type:Article
Date:1991
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Wiegrebe
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:08 Jul 2010 05:07
Last Modified:13 Mar 2014 13:48
Item ID:15726
Owner Only: item control page

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