Weimar, C. and Angerer, S. von and Wiegrebe, Wolfgang (1991) Methoxy- and Acetoxy-8-oxoberbines-Synthesis, Antitumor-Activity, and Interaction with DNA. Archiv der Pharmazie 324, pp. 509-518.
Most of the memoxy-8H-dibenzo[a,g]isoquinolin-8-ones 3a-h and their acetoxy derivatives 6a-e were synthesized by condensation of 1-oxo-1,2,3,4-tetrahydroisoquinolines 4a-c and homophthalic acid anhydrides 5a and b, ether cleavage and acetylation. These protoberberinones were tested for cytostatic activity in vitro using MDA-MB-231 mammary tumor cells and for interaction with native calf ...
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|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Wiegrebe|
|Dewey Decimal Classification:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited on:||08 Jul 2010 05:07|
|Last modified:||13 Mar 2014 13:48|