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Anthralin Derivatives - Inhibition of 5-Lipoxygenase - Antipsoriatic Efficacy

Tanzer, H. and Braun, C. and Seidel, M. and Wiegrebe, Wolfgang (1991) Anthralin Derivatives - Inhibition of 5-Lipoxygenase - Antipsoriatic Efficacy. Archiv der Pharmazie 324, pp. 841-846.

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Abstract

Inhibition of 5-lipoxygenase by anthralin (1) and 41 derivatives is determined: the acids 38 and 39, the lactones 40-42 and 9-anthrone (8) are the most potent inhibitors, the lactone 41 reaching the efficacy of nordihydroguaiaretic acid (NDGA). The results were correlated with the hydrophilic/lipophilic balance of the test compounds and their clinical efficacy as far as known. There is no ...

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Item Type:Article
Date:1991
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Wiegrebe
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:08 Jul 2010 05:09
Last Modified:13 Mar 2014 13:49
Item ID:15731
Owner Only: item control page
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