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Modulation of conformational equilibria of human H-Ras protein by metal-chelate derivatives and high pressure studied by NMR spectroscopy

URN to cite this document: urn:nbn:de:bvb:355-epub-157688

Rosnizeck, Ina (2011) Modulation of conformational equilibria of human H-Ras protein by metal-chelate derivatives and high pressure studied by NMR spectroscopy. PhD, Universität Regensburg

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Abstract (English)

The small guanine nucleotide binding protein Ras is essentially involved in the regulation of cell proliferation, differentiation and apoptosis. Alternating between an inactive GDP and an active GTP-bound form, Ras acts as molecular switch. Only active Ras can bind different effectors and transduce the signal. In about 30% of all human tumors Ras is locked in the active GTP-bound form, which ...

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Translation of the abstract (German)

Das kleine Guaninnukleotid-bindende Protein Ras ist essentiell an der Regulierung der Proliferation, Differenzierung und Apoptose von Zellen beteiligt. Es fungiert als molekularer Schalter indem es zwischen einer inkativen Form, gebunden an GDP und einer aktiven Form, gebunden an GTP wechselt. Nur aktives Ras kann verschiedene Effektoren binden und somit Signale weiterleiten. In circa 30% aller ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:5 July 2011
Referee:Prof. Dr. Dr. Hans Robert Kalbitzer
Date of exam:11 June 2010
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Research groups and research centres:Not selected
Keywords:Ras, NMR, cyclen, conformational dynamics
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:05 Jul 2011 06:35
Last Modified:13 Mar 2014 17:28
Item ID:15768
Owner Only: item control page
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