Angerer, S. von and Brandl, G. and Mannschreck, Albrecht and Weimar, C. and Wiegrebe, Wolfgang (1992) Dibenzo[a,g]quinolizin-8-ones: synthesis, estrogen receptor affinities, and cytostatic activity. Anti-Cancer Drug Design 7, pp. 351-363.
A number of acetoxy-substituted dibenzo[a,g]quinolizin-8-ones were synthesized by the reaction of 1-oxoisoquinolines with substituted homophthalic acid anhydride. All of the derivatives with acetoxy groups in positions 3 and 10 bind to the estrogen receptor. Relative binding affinities (RBA) ranged from 1.8 to 5.6 (estradiol: RBA = 100) when the substituent at C-6 was a short alkyl group. ...
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|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Wiegrebe|
|Keywords:||cytostatic activity/dibenzo[a,g]quinolizin-8-ones/estrogen receptor affinity/synthesis|
|Dewey Decimal Classification:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited on:||12 Jul 2010 07:38|
|Last modified:||13 Mar 2014 13:49|