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Dibenzo[a,g]quinolizin-8-ones: synthesis, estrogen receptor affinities, and cytostatic activity

Angerer, S. von and Brandl, G. and Mannschreck, Albrecht and Weimar, C. and Wiegrebe, Wolfgang (1992) Dibenzo[a,g]quinolizin-8-ones: synthesis, estrogen receptor affinities, and cytostatic activity. Anti-Cancer Drug Design 7, pp. 351-363.

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Abstract

A number of acetoxy-substituted dibenzo[a,g]quinolizin-8-ones were synthesized by the reaction of 1-oxoisoquinolines with substituted homophthalic acid anhydride. All of the derivatives with acetoxy groups in positions 3 and 10 bind to the estrogen receptor. Relative binding affinities (RBA) ranged from 1.8 to 5.6 (estradiol: RBA = 100) when the substituent at C-6 was a short alkyl group. ...

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Item Type:Article
Date:1992
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Wiegrebe
Keywords:cytostatic activity/dibenzo[a,g]quinolizin-8-ones/estrogen receptor affinity/synthesis
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:12 Jul 2010 07:38
Last Modified:13 Mar 2014 13:49
Item ID:15775
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