Iwasa, K. and Kamigauchi, M. and Saiki, K. and Takao, N. and Wiegrebe, Wolfgang (1993) O-Methylating Enzymes of Dopamine and Dopamine Derived Tetrahydroisoquinoline, Salsolinol. Phytochemistry 32, pp. 1443-1448.
By using an LC/API-MS system, it was demonstrated that dopamine condenses with acetaldehyde to give
salsolinol which is further metabolized to produce 6-O-methylsalsolinol (isosalsoline) which is O- and N-methylated to
provide salsolidine and N-methylisosalsoline, respectively, in several plant tissue cultures of Papaveraceae. Almost
none of the 3-O-methoxytyramine formed from dopamine was metabolized into simple isoquinoline derivatives.
Although salsolinol and 3-O-methoxytyramine were formed from dopamine, no O-methylatedsalsolinol was formed in
tissue cultures of Cynanchum vincetoxicum (Asclepiadaceae). The results suggest that the O-methylating enzymes of
salsolinol may be different to those of dopamine.
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Wiegrebe|
|Keywords:||Corydalis pallida var. tenuis, C. ochotensis var. raddeana, C. incisa; Macleaya cordata; Papaveraceae; Cynanchum vincetoxicum; Asclepiadaceae; dopamine; isoquinoline alkaloids; tissue cultures; metabolism|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||12 Jul 2010 07:52|
|Last Modified:||20 Jul 2011 22:32|