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Genome-wide analysis of aberrant CpG island methylation in human tumors

URN to cite this document: urn:nbn:de:bvb:355-epub-158137

Gebhard, Claudia (2010) Genome-wide analysis of aberrant CpG island methylation in human tumors. PhD, Universität Regensburg

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Abstract (English)

Aberrant DNA methylation of CpG islands (CGIs) is a common alteration during malignant transformation that leads to the abnormal silencing of tumor suppressor genes and plays a role in disease initiation and progression. The major aim of the present thesis was the implementation of methodologies to identify epigenetic marker genes that can be used for the diagnosis as well as for the targeted ...

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Translation of the abstract (German)

Tumorzellen zeichnen sich häufig durch ein verändertes DNA-Methylierungsmuster aus. Fehlerhafte DNA-Methylierung von CpG-Inseln (CGIs) kann zur abnormen Repression von Tumorsuppressorgenen führen und Tumorwachstum fördern. Hauptziel der vorliegenden Arbeit war es, Methoden zu etablieren, um diagnostisch oder therapeutisch verwertbare epigenetische Biomarker zu identifizieren. Desweiteren sollten ...

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Item Type:Thesis of the University of Regensburg (PhD)
Date:26 July 2010
Referee:Prof. Dr. Stephan Schneuwly and Prof. Dr. Michael Rehli
Date of exam:17 May 2010
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie
Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly)
Research groups and research centres:Not selected
Keywords:Epigenetik, DNA-Methylierung, Tumorsuppressorgene, epigenetics, DNA methylation, tumor
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Jul 2010 09:14
Last Modified:13 Mar 2014 13:51
Item ID:15813
Owner Only: item control page

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