Iwasa, K. and Kondoh, Y. and Kamigauchi, M. and Lee, D.U. and Tanner, U. and Wiegrebe, Wolfgang (1995) Effects of Pyrogallol on O-Methylation of Dopamine and Salsolinol. Phytochemistry 38 (2), pp. 335-342.
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In the cultured cells of Corydalis pallida var. tenuis, the formation of 6-O-methylated metabolites (6-D4 and 6-D7) from salsolinol-D4 (2-D4) was reduced by pyrogallol. The production of 3-O-methylated derivatives (10 and 10-D3) from dopamine was almost not affected by pyrogallol. Similar results were obtained in intact plants, though the effect of pyrogallol on methylation of C-6-OH of salsolinol in plants is smaller than that in the cultured cells. These results show that the effects of pyrogallol on the methylation of C-6-OH of salsolinol and that on the methylation of C-3-OH of dopamine are different, suggesting that the O-methylating enzymes of salsolinol and dopamine are different in C. pallida var. tenuis. The production of 3-O-methyldopamine in the presence of pyrogallol was reduced in intact plants of Cynanchum vincetoxicum, but not in the cultured cells. The effect of pyrogallol on the methylation of salsolinol was uncertain in Cyn. vincetoxicum. Both 6- and 7-O-methylations of salsolinol occur in Cyn. vincetoxicum, while only 6-O-methylation occurs in C. pallida var. tenuis. This could reveal that the O-methylating enzymes at C-6 and C-7 are different.
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Wiegrebe|
|Keywords:||Corydalis pallida var. tenuis; Papaveraceae; Cynanchum vincetoxicum; Asclepiadaceae; dopamine; salsolinol; pyrogallol; O-methylation; metabolism|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||19 Jul 2010 09:45|
|Last Modified:||19 Jul 2010 09:45|
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