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Induction of IL 2 receptor expression and cytotoxicity of thymocytes by stimulation with TCF1

Falk, Werner and Männel, D.N. and Katzer, B. and Kaltmann, B. and Krammer, P.H. and Diamantstein, T. and Dröge, W. (1985) Induction of IL 2 receptor expression and cytotoxicity of thymocytes by stimulation with TCF1. Journal of immunology (Baltimore, Md. : 1950) 135 (2), pp. 1160-1164.

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Abstract

We investigated the role of T cell cytotoxicity inducing factor 1 (TCF1) in the induction of a cytotoxic T cell response. We found that help-deficient thymocyte cultures supplied with saturating amounts of purified IL 2 did not develop CTL in a 5-day culture. The expression of cytotoxicity was dependent on the addition of TCF1 derived from the T cell hybridoma K15. TCF1 also induced proliferation ...

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Item Type:Article
Date:1985
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
3924999PubMed ID
Classification:
NotationType
AnimalsMESH
Antibodies, Monoclonal/physiologyMESH
Cell DifferentiationMESH
Cytotoxicity, ImmunologicMESH
Interleukin-1/physiologyMESH
Interleukin-2/physiologyMESH
Lymphocyte ActivationMESH
Lymphokines/physiologyMESH
MaleMESH
MiceMESH
Mice, Inbred C3HMESH
Receptors, Immunologic/immunologyMESH
Receptors, Interleukin-2MESH
Stem Cells/immunologyMESH
Suppressor Factors, ImmunologicMESH
T-Lymphocytes, Cytotoxic/metabolismMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:21 Jul 2010 05:11
Last Modified:13 Mar 2014 13:54
Item ID:15976
Owner Only: item control page

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