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Induction of interleukin 2 responsiveness in thymocytes by synergistic action of interleukin 1 and interleukin 2

Männel, D.N. and Mizel, S.B. and Diamantstein, T. and Falk, Werner (1985) Induction of interleukin 2 responsiveness in thymocytes by synergistic action of interleukin 1 and interleukin 2. Journal of immunology (Baltimore, Md. : 1950) 134 (5), pp. 3108-3110.

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Abstract

Thymocyte cultures from C3H/HeJ mice were stimulated for proliferative responses with purified preparations of interleukin 1 (IL 1) and interleukin 2 (IL 2). Synergistic responses were obtained in the absence of mitogen. In the presence of excess IL 2, the thymocyte proliferation response was strictly dependent on the amount of IL 1 in the cultures. Antibodies to IL 1 inhibited the response in a ...

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Item Type:Article
Date:1985
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
3920312PubMed ID
Classification:
NotationType
AnimalsMESH
Drug SynergismMESH
Immune ToleranceMESH
Interleukin-1/physiologyMESH
Interleukin-2/physiologyMESH
LectinsMESH
Lymphocyte ActivationMESH
MaleMESH
MiceMESH
Mice, Inbred C3HMESH
Peanut AgglutininMESH
PhenotypeMESH
Receptors, Immunologic/biosynthesisMESH
Receptors, Interleukin-2MESH
T-Lymphocytes/metabolismMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:21 Jul 2010 09:23
Last Modified:13 Mar 2014 13:54
Item ID:15982
Owner Only: item control page
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