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Inhibition of interleukin 2 production by prostaglandin E2 is not absolute but depends on the strength of the stimulating signal

Wolf, M. and Falk, Werner and Männel, D.N. and Dröge, W. (1985) Inhibition of interleukin 2 production by prostaglandin E2 is not absolute but depends on the strength of the stimulating signal. Cellular immunology 90 (1), pp. 190-195.

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Abstract

In view of the eminently important role of interleukin-2 (IL-2) in T-cell responses, and in view of reports about immune stimulatory effects of PGE2, we reinvestigated the question whether PGE2 inhibits IL-2 production. It was found that PGE2 does not inhibit IL-2 production in murine spleen cell cultures after optimal stimulation (5 micrograms/ml concanavalin A) but does inhibit at suboptimal ...

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Item Type:Article
Date:1985
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
3871360PubMed ID
Classification:
NotationType
AnimalsMESH
Concanavalin A/pharmacologyMESH
Depression, ChemicalMESH
DinoprostoneMESH
Dose-Response Relationship, DrugMESH
Interleukin-2/biosynthesisMESH
MaleMESH
MiceMESH
Prostaglandins E/pharmacologyMESH
Spleen/cytologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:21 Jul 2010 09:23
Last Modified:13 Mar 2014 13:54
Item ID:15984
Owner Only: item control page
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