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IL-1 induces high affinity IL-2 receptor expression of CD4-8- thymocytes

Falk, Werner and Männel, D.N. and Darjes, H. and Krammer, P.H. (1989) IL-1 induces high affinity IL-2 receptor expression of CD4-8- thymocytes. Journal of immunology (Baltimore, Md. : 1950) 143 (2), pp. 513-517.

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Abstract

We investigated the role of cytokines for the growth of CD4-8-thymocytes (double negative thymocytes) (DNT) in vitro and found that IL-1-induced IL-2-dependent proliferation of only the IL-2R-positive DNT subpopulation. The presence of IL-1 during the first 18 h of culture was sufficient for an optimal response and suggested that IL-1 induced DNT differentiation. We could indeed show by RNA dot ...

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Item Type:Article
Date:1989
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
2786909PubMed ID
Classification:
NotationType
AnimalsMESH
Antigens, Differentiation, T-LymphocyteMESH
Cell DifferentiationMESH
Drug SynergismMESH
Interleukin-1/pharmacologyMESH
Interleukin-2/pharmacologyMESH
Lymphocyte ActivationMESH
MiceMESH
Mice, Inbred C3HMESH
Nucleic Acid HybridizationMESH
PhenotypeMESH
RNA, Messenger/metabolismMESH
Receptors, Interleukin-2/biosynthesisMESH
T-Lymphocytes/metabolismMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:22 Jul 2010 05:00
Last Modified:13 Mar 2014 13:54
Item ID:15996
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