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Optimal induction of tumor necrosis factor production in human monocytes requires complete S-form lipopolysaccharide

Männel, D.N. and Falk, Werner (1989) Optimal induction of tumor necrosis factor production in human monocytes requires complete S-form lipopolysaccharide. Infection and immunity 57 (7), pp. 1953-1958.

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Abstract

Optimal activation of human monocytes in vitro for the biosynthesis of tumor necrosis factor was achieved only with complete S-form lipopolysaccharide. Endotoxin preparations with shorter carbohydrate chains or the lipid A component of lipopolysaccharide were not able to induce release of comparable amounts of tumor necrosis factor by monocytes under the conditions described. The same differences ...

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Item Type:Article
Date:1989
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
2453617PubMed ID
Classification:
NotationType
Cell LineMESH
Cell-Free SystemMESH
Fibrosarcoma/pathologyMESH
HumansMESH
Lipopolysaccharides/pharmacologyMESH
Monocytes/metabolismMESH
Nucleic Acid HybridizationMESH
RNA, Messenger/biosynthesisMESH
Salmonella/immunologyMESH
Tumor Cells, Cultured/pathologyMESH
Tumor Necrosis Factor-alpha/toxicityMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:08 Sep 2010 05:26
Last Modified:13 Mar 2014 13:55
Item ID:16006
Owner Only: item control page

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