Männel, D.N. and Falk, Werner
Optimal induction of tumor necrosis factor production in human monocytes requires complete S-form lipopolysaccharide.
Infection and immunity 57 (7), pp. 1953-1958.
Optimal activation of human monocytes in vitro for the biosynthesis of tumor necrosis factor was achieved only with complete S-form lipopolysaccharide. Endotoxin preparations with shorter carbohydrate chains or the lipid A component of lipopolysaccharide were not able to induce release of comparable amounts of tumor necrosis factor by monocytes under the conditions described. The same differences in the level of tumor necrosis factor mRNA were observed. Moreover, addition of these agents to appropriate monocyte-activating substances inhibited the production of tumor necrosis factor. The regulatory implications of this phenomenon are discussed.
|Institutions:|| Medicine > Lehrstuhl für Innere Medizin I|
|Nucleic Acid Hybridization||MESH|
|Tumor Cells, Cultured/pathology||MESH|
|Tumor Necrosis Factor-alpha/toxicity||MESH|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||08 Sep 2010 05:26|
|Last Modified:||20 Jul 2011 22:34|