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Normal lymphocyte responsiveness to lectins but impaired sensitivity to in vitro glucocorticoids in major depression.

Wodarz, Norbert and Rupprecht, R. and Kornhuber, J. and Schmitz, B. and Wild, K. and Braner, H. U. and Riederer, P. (1991) Normal lymphocyte responsiveness to lectins but impaired sensitivity to in vitro glucocorticoids in major depression. Journal of affective disorders 22 (4), pp. 241-248.

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Abstract

The mitogen-induced lymphocyte proliferative response and its sensitivity to in vitro (10(-10)-10(-6) M) dexamethasone (DEX) administration were investigated in 12 severely depressed patients and 13 healthy controls. Patients with major depressive disorder exhibited no impairment of lectin-induced blastogenesis, but a significantly weaker suppressive effect of in vitro DEX on 1.0 microgram/ml ...

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Item Type:Article
Date:1991
Institutions:Medicine > Lehrstuhl für Psychiatrie und Psychotherapie
Identification Number:
ValueType
1658104PubMed ID
Classification:
NotationType
Adrenocorticotropic Hormone/bloodMESH
AdultMESH
Cells, CulturedMESH
Depressive Disorder/immunologyMESH
Dexamethasone/pharmacologyMESH
FemaleMESH
HumansMESH
Hydrocortisone/bloodMESH
Immune Tolerance/immunologyMESH
Immunity, Cellular/immunologyMESH
Lymphocyte Activation/immunologyMESH
MaleMESH
Middle AgedMESH
Phytohemagglutinins/immunologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:26 Aug 2010 07:09
Last Modified:13 Mar 2014 13:59
Item ID:16325
Owner Only: item control page
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