Wodarz, Norbert and Rupprecht, R. and Kornhuber, J. and Schmitz, B. and Wild, K. and Riederer, P.
Cell-mediated immunity and its glucocorticoid-sensitivity after clinical recovery from severe major depressive disorder.
Journal of affective disorders 25 (1), pp. 31-38.
This follow-up study investigated lymphocyte blastogenesis induced by concanavalin A, phytohemagglutinin A, and pokeweed mitogen and their sensitivity to in vitro dexamethasone administration in 12 patients clinically recovered from severe major depression. Although cortisol-levels at 4.00 p.m. decreased significantly after clinical remission, mitogen-driven lymphocyte proliferative responses were unchanged when assessed intra-individually. No impairment of in vitro glucocorticoid-sensitivity of lectin-induced lymphocyte blastogenesis could be observed in clinically recovered patients. The inhibitory potency of in vitro dexamethasone was found to be inversely correlated with in vivo adrenal cortical hormone levels. There were no correlations with age, weight, sex, antidepressant medication, severity or duration of depression. No differences from age- and sex-matched healthy individuals were found. These results indicate that reduced glucocorticoid receptor sensitivity occurs only during the acute depressive illness.
|Institutions:|| Medicine > Lehrstuhl für Psychiatrie und Psychotherapie|
|Dose-Response Relationship, Drug||MESH|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||27 Aug 2010 12:22|
|Last Modified:||20 Jul 2011 22:35|