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Disturbed glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressives pretreated with metyrapone

Rupprecht, R. and Kornhuber, J. and Wodarz, Norbert and Lugauer, J. and Göbel, C. and Haack, D. and Beck, G. and Müller, O. A. and Riederer, P. and Beckmann, H. (1991) Disturbed glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressives pretreated with metyrapone. Biological psychiatry 29 (11), pp. 1099-1109.

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Abstract

We studied glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressed patients and controls, attempting to control for the confounding effect of endogenous glucocorticoids. After depletion of endogenous cortisol, depressed patients showed an attenuated suppressibility of corticotropin by dexamethasone in the face of unchanged dexamethasone plasma levels. ...

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Item Type:Article
Date:1991
Institutions:Medicine > Lehrstuhl für Psychiatrie und Psychotherapie
Identification Number:
ValueType
1651773PubMed ID
Classification:
NotationType
AdolescentMESH
Adrenocorticotropic Hormone/bloodMESH
AdultMESH
AgedMESH
Bipolar Disorder/psychologyMESH
Depressive Disorder/psychologyMESH
Dexamethasone/pharmacokineticsMESH
FemaleMESH
Homeostasis/physiologyMESH
HumansMESH
Hydrocortisone/bloodMESH
Hypothalamo-Hypophyseal System/physiopathologyMESH
MaleMESH
Metyrapone/diagnostic useMESH
Middle AgedMESH
Pituitary-Adrenal System/physiopathologyMESH
PremedicationMESH
Psychiatric Status Rating ScalesMESH
Receptors, Glucocorticoid/physiologyMESH
beta-Endorphin/bloodMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:27 Aug 2010 12:16
Last Modified:13 Mar 2014 14:00
Item ID:16336
Owner Only: item control page
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