Rupprecht, R. and Wodarz, Norbert and Kornhuber, J. and Wild, K. and Schmitz, B. and Braner, H.-U. and Müller, O. A. and Riederer, P. and Beckmann, H.
In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression.
European archives of psychiatry and clinical neuroscience 241 (1), pp. 35-40.
Twelve severely depressed patients and 13 healthy controls were studied under baseline, metyrapone and metyrapone plus dexamethasone pretreated conditions. Lymphocyte proliferation data were obtained by concanavalin A, phytohaemagglutinin and pokeweed mitogen (PWM) stimulation. There was a decrease in PWM-induced B-cell proliferation and an increase in inhibition of spontaneous leucocyte proliferation by dexamethasone added in vitro following metyrapone administration in vivo, in healthy controls, which was not present in the depressed patients. These data support the concept of a decreased functional plasticity of the glucocorticoid receptor in depression also at the cellular level.
|Institutions:|| Medicine > Lehrstuhl für Psychiatrie und Psychotherapie|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||27 Aug 2010 12:15|
|Last Modified:||20 Jul 2011 22:35|