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Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis

Echtenacher, B. and Falk, Werner and Männel, D. N. and Krammer, P. H. (1990) Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis. Journal of immunology (Baltimore, Md. : 1950) 145 (11), pp. 3762-3766.

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Abstract

By intrasplenic immunization we raised a rat mAb (mAb V1q; IgG2a, kappa) with a potent neutralizing activity against natural mouse TNF (1 microgram/ml mAb V1q/100 U/ml TNF). mAb V1q was used to study the role of endogenous TNF in experimental peritonitis induced by sublethal cecal ligation and puncture. mAb V1q persisted for over 5 days in the serum of mice injected with 100 micrograms of the ...

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Item Type:Article
Date:1990
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
2246512PubMed ID
Classification:
NotationType
AnimalsMESH
Antibodies, Monoclonal/immunologyMESH
Antibody SpecificityMESH
FemaleMESH
ImmunizationMESH
Lipopolysaccharides/toxicityMESH
Lymphocytes/physiologyMESH
MiceMESH
Mice, Inbred DBAMESH
Peritonitis/therapyMESH
RatsMESH
Rats, Inbred StrainsMESH
Tumor Necrosis Factor-alpha/physiologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:08 Sep 2010 05:24
Last Modified:13 Mar 2014 14:00
Item ID:16467
Owner Only: item control page

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