Startseite UB

Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras

Franken, S. M. and Scheidig, A. J. and Krengel, U. and Rensland, H. and Lautwein, A. and Geyer, M. and Scheffzek, K. and Goody, R. S. and Kalbitzer, Hans Robert and Pai, E. F. and Wittinghofer, A. (1993) Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras. Biochemistry 32 (33), pp. 8411-8420.

Full text not available from this repository.

at PubMed


Abstract

The three-dimensional structures and biochemical properties of two mutants of the G-domain (residues 1-166) of p21H-ras, p21 (G12D) and p21 (G12P), have been determined in the triphosphate-bound form using guanosine 5'-(beta,gamma-imido)triphosphate (GppNHp). They correspond to the most frequent oncogenic and the only nononcogenic mutation of Gly-12, respectively. The G12D mutation is the only ...

plus


Export bibliographical data



Item Type:Article
Date:1993
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Identification Number:
ValueType
8357792PubMed ID
Classification:
NotationType
Amino Acid SequenceMESH
AnimalsMESH
Base SequenceMESH
Binding SitesMESH
Circular DichroismMESH
Conserved SequenceMESH
GTP Phosphohydrolases/metabolismMESH
Genes, rasMESH
GlycineMESH
Guanosine Triphosphate/metabolismMESH
Guanylyl Imidodiphosphate/metabolismMESH
Magnesium/metabolismMESH
MammalsMESH
Models, MolecularMESH
Molecular Sequence DataMESH
Mutagenesis, Site-DirectedMESH
OligodeoxyribonucleotidesMESH
Point MutationMESH
Polymerase Chain Reaction/methodsMESH
Protein ConformationMESH
Proto-Oncogene Proteins p21(ras)/metabolismMESH
Recombinant Proteins/metabolismMESH
ThermodynamicsMESH
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:08 Sep 2010 08:38
Last Modified:08 Sep 2010 08:38
Item ID:16496
Owner Only: item control page
  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact