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An NF-kappa B-like element plays an essential role in interleukin-1-mediated costimulation of the mouse interleukin-2 promoter

Stricker, K. and Serfling, E. and Krammer, P. H. and Falk, Werner (1993) An NF-kappa B-like element plays an essential role in interleukin-1-mediated costimulation of the mouse interleukin-2 promoter. European journal of immunology 23 (7), pp. 1475-1480.

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Abstract

Interleukin-1 (IL-1) costimulation is required for efficient IL-2 synthesis and IL-2 receptor (IL-2R) expression of T cells. The molecular events leading to these effects are largely unknown. We utilized an IL-1-responsive and an IL-1-non-responsive subclone of the mouse thymoma cell line EL4 to investigate how IL-1 activates IL-2 gene expression. We correlated IL-2 promoter activity with the ...

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Item Type:Article
Date:1993
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
8325323PubMed ID
10.1002/eji.1830230712DOI
Classification:
NotationType
AnimalsMESH
Base SequenceMESH
Binding SitesMESH
Consensus SequenceMESH
DNA-Binding Proteins/physiologyMESH
Gene Expression RegulationMESH
Interleukin-1/physiologyMESH
Interleukin-2/geneticsMESH
MiceMESH
Molecular Sequence DataMESH
NF-kappa B/physiologyMESH
Nuclear Proteins/physiologyMESH
Promoter Regions, GeneticMESH
T-Lymphocytes/physiologyMESH
Transcription Factors/physiologyMESH
Tumor Cells, CulturedMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:08 Sep 2010 05:13
Last Modified:13 Mar 2014 14:01
Item ID:16498
Owner Only: item control page

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