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Activation of the mouse IL-2 gene by okadaic acid: synergy with interleukin-1

Falk, Werner and Stricker, K. and Praast, G. and Tsukitani, Y. and Krammer, P. H. and Stoeck, M. (1994) Activation of the mouse IL-2 gene by okadaic acid: synergy with interleukin-1. Lymphokine and cytokine research 13 (3), pp. 167-174.

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Abstract

Interleukin-1 (IL-1) has potent immunoregulatory and inflammatory functions. Its activity is mediated by an 80-kDa receptor on the cell surface and leads to activation of other genes. The underlying molecular events are largely unknown. We investigated the role of phosphatases in activation of the IL-2 gene in EL4 thymoma cells. We found that the protein phosphatase PP1 and PP2A inhibitor okadaic ...

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Item Type:Article
Date:1994
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
7948425PubMed ID
Classification:
NotationType
AnimalsMESH
Drug SynergismMESH
Ethers, Cyclic/pharmacologyMESH
Gene Expression Regulation/drug effectsMESH
Gene Expression Regulation, Neoplastic/drug effectsMESH
Interleukin-1/pharmacologyMESH
Interleukin-2/geneticsMESH
Interleukin-6/geneticsMESH
MiceMESH
Neoplasm Proteins/geneticsMESH
Okadaic AcidMESH
Phosphoprotein Phosphatases/antagonists & inhibitorsMESH
RNA, Messenger/geneticsMESH
RNA, Neoplasm/geneticsMESH
Tetradecanoylphorbol Acetate/pharmacologyMESH
Thymoma/pathologyMESH
Thymus Neoplasms/pathologyMESH
Tumor Cells, CulturedMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:08 Sep 2010 05:12
Last Modified:13 Mar 2014 14:01
Item ID:16500
Owner Only: item control page

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