Falk, Werner and Stricker, K. and Praast, G. and Tsukitani, Y. and Krammer, P. H. and Stoeck, M.
Activation of the mouse IL-2 gene by okadaic acid: synergy with interleukin-1.
Lymphokine and cytokine research 13 (3), pp. 167-174.
Interleukin-1 (IL-1) has potent immunoregulatory and inflammatory functions. Its activity is mediated by an 80-kDa receptor on the cell surface and leads to activation of other genes. The underlying molecular events are largely unknown. We investigated the role of phosphatases in activation of the IL-2 gene in EL4 thymoma cells. We found that the protein phosphatase PP1 and PP2A inhibitor okadaic ...
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|Institutions:||Medicine > Lehrstuhl für Innere Medizin I|
|Gene Expression Regulation/drug effects||MESH|
|Gene Expression Regulation, Neoplastic/drug effects||MESH|
|Phosphoprotein Phosphatases/antagonists & inhibitors||MESH|
|Tumor Cells, Cultured||MESH|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||08 Sep 2010 05:12|
|Last Modified:||13 Mar 2014 14:01|