Männel, D. N. and Orosz, P. and Hafner, M. and Falk, Werner
Mechanisms involved in metastasis enhanced by inflammatory mediators.
Circulatory shock 44 (1), pp. 9-13.
The enhancement of tumor metastasis by concurrent inflammatory processes is mainly due to the cytokines TNF and IL-1. In the case of TNF this effect is not restricted to metastasis models as measured by in vivo colony formation but also found in experimental model systems of spontaneous metastasis. Direct effects on the tumor cells or interference with the host NK cell system did not seem to account for the observed TNF effect. Experimental evidence from different test systems rather points to TNF- or IL-1-induced enhanced adhesion of tumor cells to the endothelial cell layer as the underlying mechanism. Blocking of integrin-matrix interactions with monoclonal antibodies or competing peptides inhibited tumor cell adhesion to endothelioma cells in vitro and lung colony formation of tumor cells in vivo.
|Institutions:|| Medicine > Lehrstuhl für Innere Medizin I|
|Killer Cells, Natural/physiology||MESH|
|Mice, Inbred C57BL||MESH|
|Tumor Necrosis Factor-alpha/pharmacology||MESH|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||08 Sep 2010 05:11|
|Last Modified:||20 Jul 2011 22:36|