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Solid-phase synthesis of H- and methylphosphonopeptides

Hoffmann, R. and Tholey, A. and Hoffmann, T. and Kalbitzer, Hans Robert (1996) Solid-phase synthesis of H- and methylphosphonopeptides. International journal of peptide and protein research 47 (4), pp. 245-253.

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Abstract

We introduce solid-phase syntheses of H- and methylphosphonopeptides, giving access for the first time to a new class of mimics for o-phosphoamino acids. The model peptides H-GlyGlyXaaAla-OH (Xaa = Ser, Thr) were synthesized on a solid-phase using Fmoc/tBu strategy and HBTU/HOBt activation by incorporation of hydroxyl-protected serine and threonine. As selectively cleavable hydroxyl-protecting ...

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Item Type:Article
Date:1996
Additional information (public):The journal of peptide research = online-Ausg.
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Identification Number:
ValueType
8738649PubMed ID
Classification:
NotationType
Magnetic Resonance SpectroscopyMESH
Phosphopeptides/chemistryMESH
PhosphorylationMESH
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:08 Sep 2010 08:27
Last Modified:08 Sep 2010 08:27
Item ID:16504
Owner Only: item control page
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