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Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase

Welker, R. and Kottler, H. and Kalbitzer, Hans Robert and Kräusslich, H. G. (1996) Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase. Virology 219 (1), pp. 228-236.

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Abstract

The Nef protein of primate immunodeficiency viruses is essential for establishing a highly productive pathogenic infection in vivo. In tissue culture, Nef is not required for infection but enhances viral infectivity. This effect is most pronounced in unstimulated primary lymphocytes and occurs in the early phase of infection prior to viral gene expression. Since Nef expression does not lead to ...

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Item Type:Article
Date:1996
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Identification Number:
ValueType
8623533PubMed ID
10.1006/viro.1996.0240DOI
Classification:
NotationType
AnimalsMESH
Cell LineMESH
Cell Line, TransformedMESH
Cercopithecus aethiopsMESH
Gene Products, nef/physiologyMESH
HIV Protease/metabolismMESH
HIV-1/physiologyMESH
HumansMESH
MutationMESH
Substrate SpecificityMESH
TransfectionMESH
Viral Proteins/metabolismMESH
Virion/physiologyMESH
Virus AssemblyMESH
nef Gene Products, Human Immunodeficiency VirusMESH
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:13 Sep 2010 08:23
Last Modified:13 Sep 2010 08:23
Item ID:16545
Owner Only: item control page
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