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Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily

Linnemann, T. and Geyer, M. and Jaitner, B. K. and Block, C. and Kalbitzer, Hans Robert and Wittinghofer, A. and Herrmann, C. (1999) Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily. The Journal of biological chemistry 274 (19), pp. 13556-13562.

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Abstract

Cellular signaling downstream of Ras is highly diversified and may involve many different effector molecules. A potential candidate is AF6 which was originally identified as a fusion to ALL-1 in acute myeloid leukemia. In the present work the interaction between Ras and AF6 is characterized and compared with other effectors. The binding characteristics are quite similar to Raf and RalGEF, i.e. ...

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Item Type:Article
Date:1999
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Identification Number:
ValueType
10224125PubMed ID
Classification:
NotationType
Amino Acid SequenceMESH
AnimalsMESH
Binding SitesMESH
Guanosine Triphosphate/metabolismMESH
HumansMESH
HydrolysisMESH
Kinesin/metabolismMESH
KineticsMESH
Molecular Sequence DataMESH
Myosins/metabolismMESH
Phosphorus IsotopesMESH
RatsMESH
Sequence Homology, Amino AcidMESH
ThermodynamicsMESH
ras Proteins/metabolismMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Deposited On:13 Sep 2010 08:06
Last Modified:16 Jan 2015 09:16
Item ID:16558
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