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Control of K⁺ channel gating by protein phosphorylation: structural switches of the inactivation gate

Antz, C. and Bauer, T. and Kalbacher, H. and Frank, R. and Covarrubias, M. and Kalbitzer, Hans Robert and Ruppersberg, J. P. and Baukrowitz, T. and Fakler, B. (1999) Control of K⁺ channel gating by protein phosphorylation: structural switches of the inactivation gate. Nature structural biology 6 (2), pp. 146-150.

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Abstract

Fast N-type inactivation of voltage-dependent potassium (Kv) channels controls membrane excitability and signal propagation in central neurons and occurs by a 'ball-and-chain'-type mechanism. In this mechanism an N-terminal protein domain (inactivation gate) occludes the pore from the cytoplasmic side. In Kv3.4 channels, inactivation is not fixed but is dynamically regulated by protein ...

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Item Type:Article
Date:1999
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Identification Number:
ValueType
10048926PubMed ID
10.1038/5833DOI
Classification:
NotationType
AnimalsMESH
Ion Channel GatingMESH
Magnetic Resonance SpectroscopyMESH
Models, MolecularMESH
PhosphorylationMESH
Potassium Channel BlockersMESH
Potassium Channels/physiologyMESH
Potassium Channels, Voltage-GatedMESH
Protein ConformationMESH
Shaw Potassium ChannelsMESH
XenopusMESH
Xenopus ProteinsMESH
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:13 Sep 2010 08:03
Last Modified:13 Sep 2010 08:03
Item ID:16561
Owner Only: item control page
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