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Conformational states of the nuclear GTP-binding protein Ran and its complexes with the exchange factor RCC1 and the effector protein RanBP1

Geyer, M. and Assheuer, R. and Klebe, C. and Kuhlmann, J. and Becker, J. and Wittinghofer, A. and Kalbitzer, Hans Robert (1999) Conformational states of the nuclear GTP-binding protein Ran and its complexes with the exchange factor RCC1 and the effector protein RanBP1. Biochemistry 38 (35), pp. 11250-11260.

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Abstract

It has been shown before by (31)P NMR that Ras bound to the nonhydrolyzable GTP analogue guanosine 5'-O-(beta, gamma-imidotriphosphate) (GppNHp) exists in two conformations which are rapidly interconverting with a rate constant of 3200 s-1 at 30 degrees C [Geyer, M., et al. (1996) Biochemistry 35, 10308-10320]. Here we show that Ran complexed with GTP also exists in two conformational states, 1 ...

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Item Type:Article
Date:1999
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Identification Number:
ValueType
10471274PubMed ID
10.1021/bi9904306DOI
Classification:
NotationType
Cell Cycle ProteinsMESH
DNA-Binding Proteins/chemistryMESH
GTP-Binding Proteins/chemistryMESH
Guanine Nucleotide Exchange FactorsMESH
Guanosine Diphosphate/chemistryMESH
Guanosine Triphosphate/chemistryMESH
Guanylyl Imidodiphosphate/chemistryMESH
HumansMESH
Macromolecular SubstancesMESH
Models, MolecularMESH
Nuclear Magnetic Resonance, BiomolecularMESH
Nuclear Proteins/chemistryMESH
Phosphorus IsotopesMESH
Protein ConformationMESH
TemperatureMESH
ThermodynamicsMESH
ran GTP-Binding ProteinMESH
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:13 Sep 2010 08:00
Last Modified:13 Sep 2010 08:00
Item ID:16564
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