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Dynamic properties of the Ras switch I region and its importance for binding to effectors

Spoerner, M. and Herrmann, C. and Vetter, I. R. and Kalbitzer, Hans Robert and Wittinghofer, A. (2001) Dynamic properties of the Ras switch I region and its importance for binding to effectors. Proceedings of the National Academy of Sciences of the United States of America: PNAS 98 (9), pp. 4944-4949.

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Abstract

We have investigated the dynamic properties of the switch I region of the GTP-binding protein Ras by using mutants of Thr-35, an invariant residue necessary for the switch function. Here we show that these mutants, previously used as partial loss-of-function mutations in cell-based assays, have a reduced affinity to Ras effector proteins without Thr-35 being involved in any interaction. The ...

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Item Type:Article
Date:2001
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Identification Number:
ValueType
2196171PubMed ID
10.1073/pnas.081441398DOI
Classification:
NotationType
Amino Acid Substitution/geneticsMESH
Binding SitesMESH
Conserved Sequence/geneticsMESH
Crystallography, X-RayMESH
Guanylyl Imidodiphosphate/metabolismMESH
HumansMESH
IsomerismMESH
KineticsMESH
LigandsMESH
Magnesium/metabolismMESH
Magnetic Resonance SpectroscopyMESH
Models, MolecularMESH
Mutation/geneticsMESH
Protein BindingMESH
Protein Structure, TertiaryMESH
Proto-Oncogene Proteins p21(ras)/metabolismMESH
Threonine/metabolismMESH
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:15 Sep 2010 09:07
Last Modified:15 Sep 2010 09:07
Item ID:16577
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